灸脐法治疗原发性痛经的代谢组学机制差异的研究.pdf

  Research on the Difference of Metabonomics Mechanism of Treatment of Primary Dysmenorrhea with Fumigating the Navel Speciality: Acupuncture and Moxibustion Author: Yin Xingling Tutor: Ma Yuxia Abstract Objective: Two treatments were selected in this study— herbs-separated moxibustion at the navel and no medicine moxibustion at the navel to cure the patients with primary dysmenorrhea, in order to observe the difference of metabolomics mechanism with the two methods,attempts to explain the mechanism of herbs-separated moxibustion at the navel in treating primary dysmenorrhea . Methods: 20 patients with primary dysmenorrhea were randomly divided into two groups, 10cases in the group of herbs-separated moxibustion at the navel; 10 cases in the group of no medicine moxibustion at the navel. Then we processed the blood and urine sample of before and after trestment and analysised metabolomics, in order to compare the differences between the two groups. Result: The metabolite spectrum of herbs-separated moxibustion at the navel and no medicine moxibustion at the navel to cure the patients with primary dysmenorrhea has undergone significant changes. The metabolite of more significant change has amino acid ,steroid and alkaoids and so on. These metabolites are mainly related to process of amino acid metabolism and steroid metabolism and so on. Moxibustion at the navel can be by reducing prostaglandin,estradiol,dopamine,norepinephrine,oxygen free radicals and calcium content ,and improving progesterone and nitric oxide to relieve the uterine smooth muscle spasm in order to alleviate dysmenorrhea. Compared with the group of no medicine moxibustion at the navel, the group of he