《Iron Oxide Nanotubes for Magnetically Guided Delivery》.pdf

www.afm-journal.de www.MaterialsV R E Iron Oxide Nanotubes for Magnetically Guided Delivery P A and pH-Activated Release of Insoluble Anticancer Drugs P L L U Zhan-Guo Yue, Wei Wei, Zuo-Xiang You, Qin-Zheng Yang, Hua Yue, Zhi-Guo Su, F and Guang-Hui Ma* which may block blood capillaries and Low solubility in water is an intrinsic property of many drugs, which hin- cause serious safety problems, or insuffi - ders the clinical use of those active ingredients. To break this bottleneck, we cient drug doses at the lesion site at low saturated concentration.[5,6] attempt to develop an iron oxide nanoparticle-based multifunctional system. Paclitaxel (PTX), isolated from the bark Firstly, we perform PEG coating and compare the feasibility of spherical of Taxus brevifolia, is a well-known anti- and rod-like iron oxide nanoparticles in a view of carcinoma cellular uptake; cancer agent, which has provided effective rod-like nanoparticles attracted our interest since they could be quickly and treatment for a wide range of carcinomas massively internalized. For paclitaxel (PTX) loading, we next transform the by interfering with microtubule breakdown