肾康宁方治疗早期糖尿病肾病临床研究.pdfVIP

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肾康宁方治疗早期糖尿病肾病临床研究.pdf

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目录中文摘要·····················································1 英文摘要 ·····················································3 引言 ······················································6 正文 ······················································7 1.研究对象与方法 ··········································7 1.1 一般资料 ·················································7 1.2 诊断标准 ·················································7 1.3 试验病例标准 ·············································8 1.4 治疗方法 ·················································9 1.5 观察指标 ·················································9 1.6 疗效评定标准 ·············································10 1.7 统计学方法 ···············································11 2. 结果 ··················································11 3. 讨论 ··················································14 4. 存在的问题和展望 ······································32 结论 ·····················································34 参考文献 ····················································35 主要英文缩略语表 ············································40 综述 ·····················································41 致谢 ·····················································51 攻读学位期间发表的学术论文目录 ······························52 作者声明 ····················································53 个人简历 ····················································54 中文摘要目的：观察具有益气养阴、健脾补肾、化痰通络作用的中药肾康宁方治疗早期糖尿病肾病的临床疗效，并初步探讨其临床作用机理。方法：选择2006年9月至2007年11月在广西中医学院第一附属医院内分泌科门诊及病房的早期糖尿病肾病患者72例，中医辨证属气阴两虚兼痰瘀阻络型。将所有患者随机分成治疗组和对照组，每组36例。各组年龄、性别、病程、并发症等方面无显著性差异（P0.05 ）。所有患者均接受常规治疗，包括糖尿病教育，合理饮食，控制血糖在理想水平，合并高血压者，控制血压等。对照组仅采用常规治疗，治疗组在常规治疗的同时加用中药肾康宁方治疗。中药每日1剂，由广西中医学院第一附属医院煎药房高压浓煎药机煎药，每剂分2袋装，每袋含药液150ml，早晚各1袋。治疗8周后，观察治疗前后早期糖尿病肾病疗效及中医证候变化情况，并对尿白蛋白排泄率（UAER ）、空腹血糖（FPG ）、餐后2 小时血糖（2hPG ）、糖化血红蛋白（HbA1C ）、血脂（TC 、TG 、LDL-C 、HDL-C ）、血同型半胱氨酸（Hcy ）、血清IV型胶原（IVC ）等指标进行比较。结果：（1 ）经统计学分析，本方治疗气阴两虚兼痰瘀阻络