《中药靶向给药系统的研究进展》.pdfVIP

37 5 2 6 5 中草药 Chinese Traditional and Herbal Drugs 64 1 张　颖1 ( , 610051) : , , , , , , , : ;; ; ; ; ; : R283. 3: A :0253 2670(2006) 05 0641 07 Advances in research on target-oriented drug delivery system of Chinese materia medica ZHA NG Ying ( Sichuan In ust rial Institut e of Antibiotic, Cheng u 610051, China) Abstract: Target-oriente rug elivery systems (T ODDS) of Chinese materia me icia ( CM M) is as- cribe as preparations in w hich active fractions or single ingre ient extracte from CMM or natural me icines are irectly elivere w ith the help of ifferent carriers to target organs target tissues an tar-, , get cells or intracellula. Recent a vances of research on TODDSs of CM M classifie accor ing to carriers, such as liposomes, microspheres, nanocapsules, an emulsions are review e . In a ition, ue to the spe- cific actions of CM M on intestinal iseases, oral colon targeting rug elivery system is consi ere sub- stantials for T ODDSs of CM M . Domestic researches on T ODDS of CM M in its initial stage are limite to formulations using single natural active ingre ient as raw material. While the fewer TODDSs using CMM active fractions or formula recipes are un erw ay , w hich relates to the tremen ous ifficulties in both estab- lishment of quality stan ar for CM M active fractions an technology for preparation of CM M Neverthe-. less one of the important goals for the evelopment on preparation of CM M is T ODDS. Key words: Chinese materia me icia ( CMM) ; target-oriente rug elivery systemy (TODDS) ; lipo- somes; microspheres; nanoparticles; emulsions; oral colon targeting rug elivery system ( OCTDDS)