新生儿缺氧缺血脑病(HIE) 七年制2010.ppt

HYPOXIC-ISCHEMIC ENCEPHALOPATHY Prof. Huimin Yu M.D. (俞惠民) Department of Pediatrics Zhejiang University School of Medicine DEFINITION HIE: Hypoxic-ischemic damage of the brain resulting from perinatal asphyxia; Brain dysfunction：encephalopathy Primary cause of permanent damage to CNS. ETIOLOGY Fetal asphyxia (80%-90%) Any process that Impairs maternal oxygenation Decreases blood flow from the mother to the placenta or from paecenta to the fetus Impairs gas exchange across the placenta or at the fetal tissure Increases fetal O2 requirement will exacerbate perinatal asphyxia ETIOLOGY Fetal as