《中药复方颈舒片对大鼠神经根型颈椎病模型感觉功能的影响》.pdf

中药复方颈舒片对大鼠神经根型颈椎病模型感觉功能的影响 窦夏睿，孙建宁，王威，张硕峰(北京中医药大学中药药理系，北京100102) 摘要：目的观察复方颈舒片对神经根型颈椎病大鼠模型感觉神经系统功能的影响。方法 利用颈椎插线法建立大鼠神经 根型颈椎病模型，测量该药物对机械痛阈和正中神经体感诱发电位(SEP)传导时间的影响。结果该药在造模后14d，可以 提高大鼠患侧机械痛阈值，中剂量组疗效最明显；对造模后患侧SEP延长的病理改变，有很好的治疗作用，而且疗效发挥较 快，造模后3d即有效果。结论复方颈舒片具有一定的改善痛觉敏感和明显的提高感觉神经传导性的作用。 关键词：复方颈舒片；神经根型颈椎病；感觉功能；药效研究 中图分类号：R961 文献标识码：A 文章编号：1001—2494(2007)08—0578—04 inRats诵tll Ra· Effectof TabletonFunctionof Nerve Cervical Jingshu SensorySystem Spondy’lotic Fllfj蛐g diculopathy DOU TraditionalChinese Xia—rui，SUN Wei，ZHANG of DrugsPharmacology， Jian—ning，WANG Shuo—feng(Department TraditionalChinese 100102，China) BeijingUniversityof Medicine，Belling To theeffectof tabletonthefunctionof nerve in ABSTRACT：OBJECTIVEobserve FufangJingshu sensorysystemexperimental Themodelof cervical wasestablished cervical model．METHODSratswith spondyloticradiculopathy spondyboticradiculopathy by and intervertebralcanal suture method．Theofmechanicalwithdrawalthresholdmediannerve e— nylon inserting changes somatosensory yoked f timeweredeterminedafterthetabletswereadministrated Sutureinser． potentialSEP)conduction intragastrically．RESULTS least 14 mechanical in causeda to ting long·lasting(atup d)andhighlyreproduciblehyperalgesiaipsilateralhindpaws，andsignificant was in median administrated withdrawal SEPconductiontime nerve．After