贞清方调节SREBP_1c减少糖尿病大鼠肾脏脂质沉积.docVIP

贞清方贞清方链脲佐菌素分：贞清方组、、模型组，另设正常组周检测尿微量白蛋白排泄率(UAE)肾脏行染色在光镜下作肾组织形态学观察P0.01）, 且SREBP-1c和FAS mRNA 的表达明显上调（P0.01）。贞清方（P0.01）贞清方（P0.01）P0.01）P0.05）贞清方（P0.0）UAE明显下降（P0.0P0.05）贞清方和胍贞清方贞清方WEN Xiu-ying, XU Ming-wang，HU Qin-jin,（ Liyuan Hospital , Tongji Medical College， Huazhong University of Science and Technology, Wuhan 430077, China） ABSTRACT: OBJECTIVE To investigate Zhenqing Recipe(ZQR) in regulation of renal lipid metabolism and its molecular mechanisms. Methods Type 2 diabetic rat model was established with feeding high-glucose and high-fat diet, and injecting low dose streptozotocin. The model rat