Five new cycloartane triterpenoids from Beesia calthifolia》.pdfVIP

Fitoterapia 103 (2015) 283–288 Contents lists available at ScienceDirect Fitoterapia journal homepage: /locate/fitote Five new cycloartane triterpenoids from Beesia calthifolia Dan-Jun Zheng a, Jing Zhou a, Qian Liu a, Wei Yao b, Min-Zhe Zhang a, Bai-Hao Shao a, Jian-Xia Mo a, Chang-Xin Zhou a, Li-She Gan a,⁎ a College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Rd., Hangzhou 310058, China b Zhejiang Chemical Industry Research Institute Co., Ltd., 387 Tianmushan Rd., Hangzhou 310023, China a r t i c l e i n f o a b s t r a c t Article history: Phytochemical study on rhizomes of Beesia calthifolia resulted in the isolation of five new (1–5) Received 3 April 2015 and three known (6–8) cycloartane triterpenoids possessing a hemiketal or ketal group at C-24 Accepted in revised form 20 April 2015 from the EtOAc fraction of 95% ethanol extract. Their structures were determined by spectroscopic Accepted 26 April 2015 and chemical methods, especially HRMS and 2D NMR techniques. Compounds 3 and 4 showed Available online 30 April 2015 potential hepatoprotective activities against D-galactosamine induced human hepatic L02 cell damage. Keywords: © 2015 Elsevier B.V. All rights reserved. Cycloartane triterpenoid Beesia calthifolia Hepatoprotective activity 2D NMR 1. Introduction