Formulation and process optimization of multiparticulate pulsatile system delivered by osmotic pressure-activated rupturable membrane》.pdfVIP

International Journal of Pharmaceutics 480 (2015) 15–26 Contents lists available at ScienceDirect International Journal of Pharmaceutics journal homepage: www.elsev /locate /ijpharm Formulation and process optimization of multiparticulate pulsatile system delivered by osmotic pressure-activated rupturable membrane Sheng-Feng Hung a,1, Chien-Ming Hsieh c,1, Ying-Chen Chen a, Cheng-Mao Lin a, Hsiu-O Ho a,*, Ming-Thau Sheu a,b,* a School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei, Taiwan b Clinical Research Center and Traditional Herbal Medicine Research Center, Taipei Medical University Hospital, Taipei, Taiwan c Department of Cosmetic Science, Providence University, Taichung City, Taiwan A R T I C L E I N F O A B S T R A C T Article history: In this study, a multiparticulate pulsatile drug delivery system activated by a rupturable controlled- Received 26 August 2014 release membrane (Eudragit1 RS) via osmotic pressure (with NaCl as the osmogent) was developed and Received in revised form 30 December 2014 characterized for omeprazole, omeprazole sodium, and propranolol HCl which have different water Accepted 4 January 2015 solubilities. Multiparticulates in pellet form for incorporation with or without the osmogent were Available online 6 January 2015 manufactured by three methods and then used to coat a polymeric membrane. Results demonstrated that drug/osmogent-containing pellets manufacture