Impaired facilitation of self-control cognition by glucose in patients with schizophrenia A randomized controlled study》.pdfVIP

Schizophrenia Research 156 (2014) 38–45 Contents lists available at ScienceDirect Schizophrenia Research journal homepage: /locate/schres Impaired facilitation of self-control cognition by glucose in patients with schizophrenia: A randomized controlled study Chung-Ming Leung a, William S. Stone b, Edwin Ho-Ming Lee a, Larry J. Seidman b,c, Eric Yu-Hai Chen a,d,⁎ a Department of Psychiatry, University of Hong Kong, Hong Kong b Department of Psychiatry, Massachusetts Mental Health Center, Division of Public Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, United States c Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, United States d State Key Laboratory of Brain and Cognitive Sciences, University of Hong Kong, Hong Kong a r t i c l e i n f o a b s t r a c t Article history: Objective: Studies in healthy individuals show that exerting self-control consumes cognitive resources, Received 24 August 2013 which reduces subsequent self-control performance. Restoring the availability of blood glucose eliminates Received in revised form 15 March 2014 this impairment. Patients with schizophrenia are found to have self-regulatory dysfunctions. This study Accepted 16 March 2014 aims to investigate whether patients (a) glucose facilitation effects will be impaired, and (b) will have ex- Available online 14 April 2014 aggerated depletion in a self-control task.