In vivo immunotoxicity of perfluorooctane sulfonate in BALBc mice Identification of T-cell receptor and calcium-mediated signaling pathway disruption through gene expression profiling of the spleen》.pdfVIP

Chemico-Biological Interactions 240 (2015) 84e93 Contents lists available at ScienceDirect Chemico-Biological Interactions journal homepage: /locate/chembioint In vivo immunotoxicity of perfluorooctane sulfonate in BALB/c mice: Identification of T-cell receptor and calcium-mediated signaling pathway disruption through gene expression profiling of the spleen * ** Qi-Yan Lv, Bin Wan , Liang-Hong Guo , Yu Yang, Xiao-Min Ren, Hui Zhang State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 10085, China a r t i c l e i n f o a b s t r a c t Article history: Perfluorooctane sulfonate (PFOS) is a persistent organic pollutant that is used worldwide and is Received 17 April 2015 continuously being detected in biota and the environment, thus presenting potential threats to the Received in revised form ecosystem and human health. Although PFOS is highly immunotoxic, its underlying molecular mecha- 5 June 2015 nisms remain largely unknown. The present study examined PFOS-induced immunotoxicity in the Accepted 30 July 2015 mouse spleen and explored its underlying mechanisms by gene expression profiling. Oral exposure of Available online 20 August 2015 male BALB/c mice for three weeks followed by o