Prognostic factors in nasopharyngeal carcinoma investigated by computer tomography — an analysis of 659 patients》.pdf

Radiotherapy and Oncology, 23 (1992) 79-93 @ 1992Elsevier Science Publishers B.V. All rights reserved. 0167-8140/92/$05.00 79 RADION 00940 Prognostic factors in nasopharyngeal carcinoma investigated by computer tomography an analysis of 659 patients P. Ten, W. Shiu, S. F. Leung and W. Y. Lee Department of Clinical Oncology,Prince of Wales Hospital, Shatin, N.T., Hong Kong (Received 18April 1991,revision received 17 September 1991,accepted 29 October 1991) Key words: Computed tomography; Prognostic factors; NPC Summary A total of 659 freshly diagnosed nasopharyngeal carcinoma (NPC) (1984-1987), were investigated by computed tomography (CT), treated with locoregional radiotherapy to radical dose, and given neoa~uvant chemotherapy (CHEMO) with 2-3 courses of cisplatinum and 5-ftuorouracil for bulky (~4 cm) cervical nodal metastasis and booster radiotherapy (PPB) for para- pharyngeal disease. All except 15 patients were fully evaluable with complete data entry till death or to the last follow-up (minimum 2 years). The data have been analysed extensively to identify variables of potential prognostic significance. The assessed factors include patients sex and age, nasal involvement (NAS), oropharyngeal involvement (ORO), parapharyngeal involvement (PAR), muscle involvement (MU), skull base involvement (BS), cranial nerves (II-VIII) palsy (CN1), cranial nerves (IX-XII) palsy (CN2), intracranial extension (IC), laryngopharyngeal extension (HYP), confinement to nasopharynx (NP), Hos N-stage (Nho), maxi