Prothrombotic genetic risk factors are associated with an increased risk of liver fibrosis in the general population The Rotterdam Study》.pdf

Research Article Prothrombotic genetic risk factors are associated with an increased risk of liver fibrosis in the general population The Rotterdam Study 1 1 1,2 3 Elisabeth P.C. Plompen , Sarwa Darwish Murad , Bettina E. Hansen , Daan W. Loth , 4 1 3 3,5 Jeoffrey N.L. Schouten , Pavel Taimr , Albert Hofman , André G. Uitterlinden , Bruno H. Stricker3,5, Harry L.A. Janssen1,6, Frank W.G. Leebeek7,⇑ 1Dept. of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands; 2Dept. of Public Health, Erasmus MC University Medical Center, Rotterdam, The Netherlands; 3Dept. of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands; 4Dept. of Gastroenterology and Hepatology, University Hospital Ghent, Ghent, Belgium; 5Dept. of Internal Medicine, Erasmus MC University Medical Center, Rotterdam, The Netherlands; 6Toronto Centre for Liver Disease, Toronto Western and General Hospital, University Health Network, Toronto, Ontario, Canada; 7Dept. of Hematology, Erasmus MC University Medical Center, Rotterdam, The Netherlands Background Aims:The coagulation system is known to be Conclusions: Participants carrying the FVL mutation or pro- involved in fibrogenesis in patients with liver disease. We inves- thrombin G20210A variant have an increased risk of c