Puerarin alleviates noise-induced hearing loss via affecting PKCγ and GABAB receptor expression》.pdf

Journal of the Neurological Sciences 349 (2015) 110 –116 Contents lists available at ScienceDirect Journal of the Neurological Sciences j ournal homepage: /l ocate/ jns Puerarin alleviates noise-induced hearing loss via affecting PKCγ and GABAB receptor expression Juan Qu a,b,1, Yong-Hui Liao a,1, Zhen-Zhen Kou a,1, Yan-Yan Wei a, Jing Huang a, Jing Chen a, Yuchio Yanagawa c, Sheng-Xi Wu a, Ming Shi d,⁎, Yun-Qing Li a,⁎⁎ a Department of Anatomy, Histology and Embryology, K.K. Leung Brain Research Centre, Fourth Military Medical University, Xian 710032, China b Department of Otolaryngology, Xijing Hospital, Fourth Military Medical University, Xian 710032, China c Department of Genetic and Behavioral Neuroscience, Gunma University Graduate School of Medicine, Maebashi 371-8511, Japan d Department of Neurology, Xijing Hospital, Fourth Military Medical University, Xian 710032, China a r t i c l e i n f o a b s t r a c t Article history: Noise-induced hearing loss (NIHL) often results from prolonged exposure to high levels of noise. Our previous Received 10 October 2014 study revealed that during the development of NIHL, the expression of protein kinase C γ subunit (PKCγ) and Received in revised form 1 December 2014 GABA receptor (GABA R) was changed within the cochlear nuclear complex (CNC), suggesting that these B B Accepted 28 December 2014 molecules might be the potential targets for the treatment of NIHL. As an extending study, here w