Quadrupole time-of-flight mass spectrometry as a powerful tool for demystifying traditional Chinese medicine》.pdfVIP

Trends in Analytical Chemistry 72 (2015) 169–180 Contents lists available at ScienceDirect Trends in Analytical Chemistry journal homepage: /locate/trac Quadrupole time-of-flight mass spectrometry as a powerful tool for demystifying traditional Chinese medicine Zhengxiang Zhang a, Tao Bo a, Yu Bai b, Min Ye c, Rong An a, Fafeng Cheng d, Huwei Liu b,* a Agilent Technologies (China) Co., Ltd., Beijing 100102, China b Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China c State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China d School of Basic Medical Sciences, Beijing University of Chinese Medicine, Beijing 100029, China A R T I C L E I N F O A B S T R A C T Keywords: Traditional Chinese medicine (TCM) has been effective in prevention and treatment of chronic diseases Active ingredient in a synergic manner with mild healing effects and lower side effects than Western medicines. Research- Intervention effect Metabolomics ers have made great efforts to explore the real theory of TCM for many years with different strategies. Quadrupole time-of-flight mass With the rapid advances in instrumentation in chromatography and mass spectrometry, more scientific spectrometry