PTEN C-Terminal Deletion Causes Genomic Instability and Tumor Development》.pdf

Cell Reports Article PTEN C-Terminal Deletion Causes Genomic Instability and Tumor Development Zhuo Sun,1,2 Chuanxin Huang,2 Jinxue He,2 Kristy L. Lamb,2 Xi Kang,1,2 Tingting Gu,2 Wen Hong Shen,2,* and Yuxin Yin1,2,* 1Institute of Systems Biomedicine, Department of Pathology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, PRC 2Department of Radiation Oncology, Weill Medical College of Cornell University, New York, NY 10065, USA *Correspondence: wes2007@ (W.H.S.), yinyuxin@ (Y.Y.) /10.1016/j.celrep.2014.01.030 This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-No Derivative Works License, which permits non-commercial use, distribution, and reproduction in any medium, provided the original author and source are credited. SUMMARY These findings suggest that C-terminal PTEN plays a significant role in suppressing neoplasm. Tumor suppressor PTEN controls genomic stability In addition to somatic PTEN alterations in a variety of sporadic and inhibits tumorigenesis. The N-terminal phospha- tumor types, germline PTEN mutations are associated with tase domain of PTEN antagonizes the PI3K/AKT a range of hereditary tumor predisposition syndromes such pathway, but its C-terminal function is less defined. as Cowden syndrome (Marsh et al., 1998a, 1998b). Cowden Here, we describe a knockin mouse model of a syndrome is an autosomal dominant disorder ch