Radiation induced liver disease A clinical update》.pdf

Journal of the Egyptian National Cancer Institute (2015) xxx, xxx–xxx Cairo University Journal of the Egyptian National Cancer Institute /locate/jnci Review Radiation induced liver disease: A clinical update R. Benson a, R. Madan a,*, R. Kilambi b, S. Chander a a Department of Radiation Oncology, All India Institute of Medical Sciences, New Delhi 110029, India b Department of Gastrointestinal Surgery and Liver Transplant, All India Institute of Medical Sciences, New Delhi 110029, India Received 3 June 2015; revised 26 July 2015; accepted 4 August 2015 KEYWORDS Abstract Radiation-induced liver disease (RILD) or radiation hepatitis is a sub-acute form of liver Radiation induced liver dis- injury due to radiation. It is one of the most dreaded complications of radiation which prevents ease; radiation dose escalation and re-irradiation for hepatobiliary or upper gastrointestinal malignan- Patho-physiology; cies. This complication should be kept in mind whenever a patient is planned for irradiation of these Risk factors; malignancies. Although, incidence of RILD is decreasing due to better knowledge of liver tolerance, Management improved investigation modalities and modern radiation delivery techniques, treatment options are still limited. In this review article, we have focussed on patho-physiology, risk factors, prevention and management of RILD. 2015 The Au