Radiolabeled γ-polyglutamic acid complex as a nano-platform for sentinel lymph node imaging》.pdf

Journal of Controlled Release 194 (2014) 310 –315 Contents lists available at ScienceDirect Journal of Controlled Release journal homepage: www. / locate/jconrel Radiolabeled γ-polyglutamic acid complex as a nano-platform for sentinel lymph node imaging Kohei Sano a, Yuriko Iwamiya a, Tomoaki Kurosaki b, Mikako Ogawa c, Yasuhiro Magata c, Hitoshi Sasaki b, Takashi Ohshima a, Minoru Maeda a, Takahiro Mukai a,d,⁎ a Department of Biomolecular Recognition Chemistry, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan b Department of Hospital Pharmacy, Nagasaki University Hospital of Medicine and Dentistry, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan c Photon Medical Research Center, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, Shizuoka 431-3192, Japan d Department of Biophysical Chemistry, Kobe Pharmaceutical University, 4-19-1 Motoyama Kitamachi, Higashinada-ku, Kobe 658-8558, Japan a r t i c l e i n f o a b s t r a c t Article history: We established a ternary anionic complex constructed with polyamidoamine dendrimer (4th generation; G4) mod- Received 15 July 2014 ified with chelating agents (diethylenetriamine pentaacetic acid (DTPA) derivative), polyethyleneimine (PEI), and Accepted 26 August 2014 γ-polyglutamic acid (PGA) as a safe nano-platform for molecular imaging. We prepared indium-111-labeled Available online 18 September 2014 DTPA-G4/PEI/γ-PGA, and evaluated the effectiveness as a nuclear imaging probe for senti