Reactive oxygen species sources and biomolecular oxidative damage induced by aflatoxin B1 and fumonisin B1 in rat spleen mononuclear cells》.pdf

Reactive oxygen species sources and biomolecular oxidative damage induced by aflatoxin B1 and fumonisin B1 in rat spleen mononuclear cells》.pdf

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Reactive oxygen species sources and biomolecular oxidative damage induced by aflatoxin B1 and fumonisin B1 in rat spleen mononuclear cells》.pdf

Toxicology 302 (2012) 299–307 Contents lists available at SciVerse ScienceDirect Toxicology j o u r n a l h o m e p ag e: w w w. elsev /locate/toxicol Reactive oxygen species sources and biomolecular oxidative damage induced by aflatoxin B1 and fumonisin B1 in rat spleen mononuclear cells Verónica S. Mary 1, Martín G. Theumer ∗,1, Silvina L. Arias, Héctor R. Rubinstein Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI), CONICET, Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba X5000HUA, Argentina a r t i c l e i n f o a b s t r a c t Article history: Aflatoxin B1 (AFB1 ) and fumonisin B1 (FB1 ) are mycotoxins widely found as cereal contaminants. Their Received 2 May 2012 immunotoxicities predispose to infectious diseases and may alter the tumor immunosurveillance of Received in revised form 27 August 2012 human and animals, but the mechanisms underlying have not been fully elucidated, and the induc- Accepted 28 August 2012 tion of oxidative stress has been proposed as a probable mechanism. This work was aimed at evaluating Available online 5 September 2012 in spleen mononuclear cells (SMC) from Wistar rats the effects of the exposure, in vitro for up to 48 h, to 20 M AFB1, 10 M FB1 and AFB1 –FB1 mixture (MIX), over cellular oxidative status, as well as at eluci- Keywords:

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