Reactive oxygen species sources and biomolecular oxidative damage induced by aflatoxin B1 and fumonisin B1 in rat spleen mononuclear cells》.pdf
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Reactive oxygen species sources and biomolecular oxidative damage induced by aflatoxin B1 and fumonisin B1 in rat spleen mononuclear cells》.pdf
Toxicology 302 (2012) 299–307
Contents lists available at SciVerse ScienceDirect
Toxicology
j o u r n a l h o m e p ag e: w w w. elsev /locate/toxicol
Reactive oxygen species sources and biomolecular oxidative damage induced by
aflatoxin B1 and fumonisin B1 in rat spleen mononuclear cells
Verónica S. Mary 1, Martín G. Theumer ∗,1, Silvina L. Arias, Héctor R. Rubinstein
Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI), CONICET, Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Universidad Nacional de
Córdoba, Córdoba X5000HUA, Argentina
a r t i c l e i n f o a b s t r a c t
Article history: Aflatoxin B1 (AFB1 ) and fumonisin B1 (FB1 ) are mycotoxins widely found as cereal contaminants. Their
Received 2 May 2012 immunotoxicities predispose to infectious diseases and may alter the tumor immunosurveillance of
Received in revised form 27 August 2012 human and animals, but the mechanisms underlying have not been fully elucidated, and the induc-
Accepted 28 August 2012 tion of oxidative stress has been proposed as a probable mechanism. This work was aimed at evaluating
Available online 5 September 2012
in spleen mononuclear cells (SMC) from Wistar rats the effects of the exposure, in vitro for up to 48 h, to
20 M AFB1, 10 M FB1 and AFB1 –FB1 mixture (MIX), over cellular oxidative status, as well as at eluci-
Keywords:
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