Recent advances in understanding the roles of vascular endothelial cells in allergic inflammation》.pdf

Allergology International xxx (2015) 1e9 Contents lists available at ScienceDirect Allergology International journal homepage: http://www.elsevier .com/locate/alit Review article Recent advances in understanding the roles of vascular endothelial cells in allergic inflammation * Tetsuo Shoda , Kyoko Futamura, Kanami Orihara, Maiko Emi-Sugie, Hirohisa Saito, Kenji Matsumoto, Akio Matsuda Department of Allergy and Immunology, National Research Institute for Child Health and Development, Tokyo, Japan a r t i c l e i n f o a b s t r a c t Article history: Allergic disorders commonly involve both chronic tissue inflammation and remodeling caused by Received 23 March 2015 immunological reactions to various antigens on tissue surfaces. Due to their anatomical location, vascular Received in revised form endothelial cells are the final responders to interact with various exogenous factors that come into 30 July 2015 contact with the epithelial surface, such as pathogen-associated molecular patterns (PAMPs) and anti- Accepted 10 August 2015 Available online xxx gens. Recent studies have shed light on the important roles of endothelial cells in the development and exacerbation of allergic disorders. For instance, endothelial cells have the greatest potential to produce several key molecules th