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Recent Progress of Colorimetric Assays Based on Gold Nanoparticles for Biomolecules》.pdf
CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
Volume 42, Issue 3, March 2014
Online English edition of the Chinese language journal
Cite this article as: Chin J Anal Chem, 2014, 42(3), 307–314. REVIEW
RecentProgressofColorimetricAssaysBasedonGold
NanoparticlesforBiomolecules
1 1,2 1 1 1,
CHEN Wen-Wen , GUO Yong-Ming , ZHENG Wen-Shu , XIANYU Yun-Lei , WANG Zhuo *,
JIANG Xing-Yu1,*
1
Chinese Academy of Sciences, Beijing Engineering Research Center for BioNanotechnology Key Lab for Biological Effects of Nanomaterials
and Nanosafety, Beijing 100190, China
2
College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang 473061, China
Abstract: Biochemical analysis assays based on colorimetric methods using gold nanoparticles have many advantages such as high
sensitivity, good selectivity, naked-eyes readout and complex instruments free. These methods have good prospects in applications.
This review mainly focuses on colorimetric assays applying gold nanoparticles for biomolecules detection.
Key Words: Colorimetric assays; Gold nanoparticles; Biomolecules analysis; Review
1 Introduction including small molecules, metal ions, proteins, nucleic acids,
tumor cells and pathogens can be easily detected. AuNPs
Gold nanoparticles (AuNPs) present a very high molar sensors do not rely on any specialized instruments, and the
extinction coefficient (for instances, the extinction coefficient colorimetric signal can be easily observe
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