Redoxal, an inhibitor of de novo pyrimidine biosynthesis, augments APOBEC3G antiviral activity against human immunodeficiency virus type 1》.pdf
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Redoxal, an inhibitor of de novo pyrimidine biosynthesis, augments APOBEC3G antiviral activity against human immunodeficiency virus type 1》.pdf
Virology 484 (2015) 276 –287
Contents lists available at ScienceDirect
Virology
journal homepage: /locate/yviro
Redoxal, an inhibitor of de novo pyrimidine biosynthesis, augments
APOBEC3G antiviral activity against human immunodeficiency virus
type 1
a,b d e a f
Erez Pery , Ann Sheehy , N. Miranda Nebane , Vikas Misra , Marie K. Mankowski ,
e e f a,c,n
Lynn Rasmussen , E. Lucile White , Roger G. Ptak , Dana Gabuzda
a Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, MA 02115, United States
b Department of Pathology, Harvard Medical School, Boston, MA 02115, United States
c Department of Neurology (Microbiology), Harvard Medical School, Boston, MA 02115, United States
d Department of Biology, College of the Holy Cross, Worcester, MA 01610, United States
e Southern Research Institute High Throughput Screening Center, Birmingham, AL 35205, United States
f Southern Research Institute, Department of Infectious Disease Research, Frederick, MD 21701, United States
a r t i c l e i n f o a b s t r a c t
Article history: APOBEC3G (A3G) is a cytidine deaminase that restricts HIV-1 replication by inducing G-to-A hypermu-
Received 13 April 2015 tation in viral DNA; deamination-independent mechanisms are also implicated. HIV-
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