Relationship between theta-phase gamma-amplitude coupling and attention-deficithyperactivity behavior in children》.pdf

Neuroscience Letters 590 (2015) 12–17 Contents lists available at ScienceDirect Neuroscience Letters j o u rn al h omepage: w w w. elsev /locate/neulet Research article Relationship between theta-phase gamma-amplitude coupling and attention-deficit/hyperactivity behavior in children Jun Won Kim a,b , Jaewon Lee c,∗ , Hyun-Jin Kim d , Young Sik Lee e , Kyung Joon Min e a Division of Child and Adolescent Psychiatry, Department of Psychiatry, Seoul National University College of Medicine, Seoul, South Korea b Department of Psychiatry, Graduate School, Chung-Ang University, Seoul, South Korea c Addiction Brain Center, Eulji Addiction Institute, Gangnam Eulji Hospital, Eulji University, Seoul, South Korea d Division of Child and Adolescent Psychiatry, Department of Psychiatry and Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, Seoul, South Korea e Department of Psychiatry, Chung-Ang University, College of Medicine, Seoul, South Korea h i g h l i g h t s • Theta-phase gamma-amplitude coupling (TGC) was analyzed as measured by scalp EEG. • The Continuous Performance Test (CPT) and EEG were performed. • An instantaneous phase method proposed by Cohen was used. • Significant negative partial correlations between TGC and the CPT. • TGC is a promising neurophysiological marker for ADHD behavior in children. a r t i c l e i n f o a b s t r a c t Article history: The Continuous Performance Test (CPT) is a valuable tool for assessing behavior in attention- Received 28 August 2014 deficit/hyperactivity disorder (ADHD). Quantitative ele