Relationship Between Vertebral Fracture Burden, Height Loss, and Pulmonary Function in Postmenopausal Women With Osteoporosis》.pdf

Journal of Clinical Densitometry: Assessment Management of Musculoskeletal Health, vol. -, no. -, 1e6, 2015 Copyright 2015 by The International Society for Clinical Densitometry 1094-6950/-:1e6/$36.00 /10.1016/j.jocd.2015.02.004 Original Article Relationship Between Vertebral Fracture Burden, Height Loss, and Pulmonary Function in Postmenopausal Women With Osteoporosis ,1 2 1 3 1 John H. Krege, * David Kendler, Kelly Krohn, Harry Genant, Jahangir Alam, Pierre-Yves Berclaz,1 Barbara Coffey,1 and Corina Loghin1 1Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA; 2 University of British Columbia, Vancouver, ON, Canada; and 3 University of California San Francisco, San Francisco, CA, USA Abstract The purpose of this analysis was to assess the association of osteoporosis-related vertebral fracture burden and pulmonary function. This study also examined the relationship between vertebral fracture burden and height loss, estimated by arm span height. This was a single-site and single-visit study. Patients had a history of at least 1 moderate or severe vertebral fracture. Vertebral fracture burden was quantified using the spinal deformity index (SDI). Pulmonary function during inspiration was determined by spirometry. Forty-one women aged 70e91 completed the study. Vertebral fracture burden negatively correlated with forced inspiratory vital capacity and inspi- ratory time. For each unit increase in SDI, forced ins