Structure activity optimization of 6H-pyrrolo[2,3-e][1,2,4]triazolo[4,3-a]pyrazines as Jak1 kinase inhibitors》.pdfVIP

Bioorganic Medicinal Chemistry Letters 25 (2015) 4399–4404 Contents lists available at ScienceDirect Bioorganic Medicinal Chemistry Letters journal homepage: /locate/bmcl Structure activity optimization of 6H-pyrrolo[2,3-e][1,2,4]triazolo [4,3-a]pyrazines as Jak1 kinase inhibitors Michael Friedman a,⇑, Kristine E. Frank b, Ana Aguirre b, Maria A. Argiriadi a, Heather Davis a, Je