《MR三回波序列在大鼠非酒精性脂肪肝模型中的应用.》.pdf

中国医学影像技术 2014年第 3O卷第 2期 ChinJMedImagingTechnol，2014，Vol30，No2 · 189 · ◆◆◆实验研究 Application oftriple。。echogradient_。echosequence in ratmodelsofnonalcoholicfattyliver HAN Cheng—kun ，HAN Hai—wei，CHEN Shi ， ZHUANGBi—mei，ZHANGHui—jie，ZHUANGXiong-jie (1．DepartmentofRadiology，2．DepartmentofDiabetesandE 0cr 0Z0g ，theFirst AffiliatedHospitalofXiamenUniversity，Xiamen361003，China) EAbstract] Objective Toexplorethefeasibilityoftriple-echogradient—echosequenceinmeasuringfatcontentofnonalco-· holicfattyliverinratmodels．Methods Totally75ratswererandomlydividedintocontrolgroupandhighfatgroup．Tri— ple—echogradient—echosequencescanningwasperformedon3．0T MR scannerafter2，4，6，8，10weeksfeeding．Theliver wasartificiallydividedintoleftandright，and9ROIsweretakenatthreecontinuouslevelsofmaximum liver．Signalinten— sity (SI)wasthencalculatedandthenaveraged．T2 effectwascorrected，andfatcontentswerecalculated．Fatcontents ofnonalcoholicfattyliverofratsobservedontriple—echogradient—echosequenceimagesandpathologywerecompared．Re— suits Fatcontentsofliverofhighfatgroupshowedbytriple-echogradient—echosequenceandpathologywere (23．16士 13．37)％ and(36．13±24．39) ，whileofcontrolgroupwere(2．27±1．31)％and(2．72士1．67) ，respectively，which werepositivelycorrelated (r一0．96，P0．01)．Bland Altman curveanalysisshowedthattheconsistencywasvery good．Conclusion Triple—echogradient—echosequenceisasafe，non—invasivewaytomonitorfatcontentsofnonalcoholic fattyliverofratmodelsdynamically，andthereforemightbeusedforguidingclinicalintervention． [Keywords] Fattylive，nonalcoholic；Magneticresonanceimaging；Triple-echogradient—echosequence MR三回波序列在大鼠非酒精性 脂肪肝模型中的应