第九章合成抗菌药.pptVIP

第九章  化学治疗药　 Chemotherapeutic Agents What is chemotherapy?　 The prevention or treatment of disease by the use of chemical substances. The term is some times restricted to the treatment of infectious diseases with antibiotics and other drugs or to the control of cancer with antimetabolites and similar drugs. 第一节　  喹诺酮类抗菌药 Quinolone Antimicrobial Agents 诺氟沙星　Norfloxacin 氟哌酸 Synthesis Physical and Chemical Properties ? Acidity and basicity: 在醋酸，盐酸或氢氧化钠液中易溶 ? Stability: 室温下相对稳定、光照分解、脱羧 ? Identification: 叔胺反应(与丙二酸，醋酐反应显红棕色) 有机氟化物的鉴别反应 Action Mechani