《Liver-gut axis in the regulation of iron homeostasis》.pdfVIP

Online Submissions: World J Gastroenterol 2007 September 21; 13(35): 4737-4745 World Journal of Gastroenterology ISSN 1007-9327 wjg@ © 2007 WJG. All rights reserved. TOPIC HIGHLIGHT Nathan Subramaniam, PhD, Series Editor Liver-gut axis in the regulation of iron homeostasis Deepak Darshan, Gregory J Anderson Deepak Darshan, Gregory J Anderson, Iron Metabolism cytochrome B or DcytB is a strong candidate) and a Laboratory, The Queensland Institute of Medical Research, ferrous iron transporter known as divalent metal-ion Brisbane, Australia [1,2] transporter (DMT1) on the brush border membrane . Correspondence to: Gregory J Anderson, PhD, Iron Heme iron, on the other hand, appears to be absorbed Metabolism Laboratory, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane Queensland through a separate system, and a recently identifi ed apical 4029, Australia. greg.anderson@.au membrane protein, HCP1, has emerged as a candidate Telephone: +61-7-3362-0187 Fax: +61-7-3362-0191 heme transporter[3]. Irrespective of the form in which iron Received: 2007-03-30 Accepted: 2007-04-14 crosses the brush border, enterocytes export iron into the