《5-单硝酸异山梨酯脉冲控释片的家犬体内药动学》.pdfVIP

Care＆Res2006Feb；6(1) 药学服务与研究Pharm 孙学惠，等．5单硝酸异山梨酯脉冲控释片的家犬体内药动学 ·论 著· 5一单硝酸异山梨酯脉冲控释片的家犬体内药动学 孙学惠1，郭 涛¨，隋 因1，宋洪涛2，刘 涛1 (1．沈阳军区总医院药剂科，沈阳110016；2．南京军区福州总医院药学科，福州350025) [摘要] 机化方法将家犬6条分成两组，以市售单硝酸异山梨酯片为对照制剂，交叉灌服自制IS-5一MN脉冲控释片和市售单硝酸异山 梨酯片，采用气相色谱电子捕获法测定血药浓度，考察自制IS-5一MN脉冲控释片在体内的脉冲控释效果。结果：Ⅲ型(体外时 滞为3h的脉冲片)IS-5一MN脉冲控释片在家犬体内的时滞为2．6h，市售IS-5MN片的时滞为0．25h，而C…、AUC等两者无 明显差异。结论：本研究制备的脉冲释放制剂为防治心血管疾病凌晨发作提供了一个良好的剂型选择，达到了设计要求。 [关键词]单硝酸异山梨酯；脉冲疗法，药物；药代动力学；色谱法，气相；狗 969．1 A 1671 0021—04 [中图分类号]R [文献标识码] [文章编号] 2838(2006)01 Theinvivo ofisosorbide-5。mononitratereleasetabletsin pharmacokinetics pulsatile dogs SUNRue—Huil，GUOTao”，SUIYinl，SONG of of Hong—Ta02，LIUTa01(1．DepartmentPharmacy，GeneralHospital of General ofNanjing ShenyangMilitaryRegion，Shenyang110016，China；2．DepartmentPharmacy，FuzhouHospital 350025，China) MilitaryRegion，Fuzhou the and invivoof [ABSTRACT]Objective：Tostudypharmacokineticsbioavailability into releasetablets withthoseoftheconventionaltablets．Methods：Sixwere divided pulsatile bycomparison dogs randomly IS-5MN release h were tWO HI tablets，whosetimewas3 invitro，andconventionaltablets groups．The pulsatile lag gavaged and concentrationsin were with dogs plasma of：IS-5一MN quantifiedbygaschromatographyelectron-capture ECD)．The behaviorofthetabletsinvivowasevaluatedthe pharmaceutical by lag