《Application of High Performance Liquid Chromatography to Separation of Novel Chiral Tetrahedral Heterometal Clusters》.pdfVIP

942 Chinese Chemical Letters Vol. 14, No. 9, pp 942 – 945, 2003 /journal/ccl.html Application of High Performance Liquid Chromatography to Separation of Novel Chiral Tetrahedral Heterometal Clusters Xin Yi ZHU, Wei Qiang ZHANG, Yu Hua ZHANG, Li Ren CHEN, Yong Min LI* Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000 Abstract: A series of novel chiral tetrahedral heterometal clusters have firstly been separated on cellulose tris-(3,5-dimethylphenylcarbamate) stationary phase by high performance liquid chrom- atography, using hexane as the mobile phase with various alcohols as modifiers. Keywords: Chiral stationary phase, cellulose tris-(3,5-dimethylphenylcarbamate), mobile-phase composition, chiral tetrahedral clusters, enantioseparation. Chiral tetrahedral heterometal clusters have aroused growing interest because of their potential application as asymmetric reaction catalysts1.Using a framework chirality clus- ter as the catalyst, it would not only bring a new concept in the asymmetric catalysis, in which the most asymmetric induction originates from the central or planar chirality of P or N ligand, but also extend the methodology in the designs of new chiral catalysts. Alth- 2,3 ough a number of chiral tetrahedral transition metal clusters have been synthesized , enantioseparation of the chiral clusters was still a major proble