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《Effect of S1P5 on proliferation and migration of human esophageal cancer cells》.pdf
Online Submissions: /1007-9327office World J Gastroenterol 2010 April 21; 16(15): 1859-1866
wjg@ ISSN 1007-9327 (print)
doi:10.3748/wjg.v16.i15.1859 © 2010 Baishideng. All rights reserved.
ORIGINAL ARTICLE
Effect of S1P5 on proliferation and migration of human
esophageal cancer cells
Wei-Min Hu, Li Li, Bao-Qian Jing, Yong-Sheng Zhao, Chao-Li Wang, Li Feng, Yong-En Xie
Wei-Min Hu, Department of Microbiology and Immunology, and migration to S1P and S1P5 expression was evaluated
North Sichuan Medical College, Nanchong 637007, Sichuan by 3(4,5dimethylthiazol2yl)2,5diphenyl tetrazolium
Province, China bromide and migration assay, respectively.
Li Li, Bao-Qian Jing, Chao-Li Wang, Li Feng, Yong-En Xie,
Institute of Immunology and Molecular Biology, North Sichuan RESULTS: Both normal human esophageal mucosal epi-
Medical College, Nanchong 637007, Sichuan Province, China
thelium and Eca109 cells expressed S1P1, S1P2, S1P3
Yong-Sheng Zhao, Department of Thoracic Surgery, Affiliated
and S1P5, respectively. Esophageal mucosal epithelium
Hospital of North Sichuan Medical College, Nanchong 637007,
Sichuan Province, China expressed S1P5 at a higher level than Eca109 cell line.
Author contributions: Hu WM and Jing BQ designed the S1P5 overexpressing Eca109 cells displayed spindle cell
research; Hu WM and Li L performed the majority of experi
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