《AMPA受体正向变构调节剂CX717研究进展》.pdfVIP

IntPharm ·261· Res，V01．40，No．3，June，2013 国际药学研究杂志2013年6月第40卷第3期J ·综 述· AMPA受体正向变构调节剂CX717研究进展 贺艺超1”，肖 典1，齐倩倩1…，赵国明1，周辛波1 [摘要] 降低AMPA受体失活或降敏的速度从而提高突触的活性，与阿尔茨海默病、帕金森病、抑郁症和注意力缺陷多动症等疾病的 治疗密切相关。本文主要综述CX717在化学结构、药代动力学、毒理学和药效学方面的研究进展。 [关键词]AMPA受体；正向变构调节剂；CX717 [中图分类号]R916．2 [文献标志码】 A [文章编号]1674-0440(2013)03-0261-04 CX717嬲aallostericmodulatorof positive acid advances methyl-4一isoxazole-propionicreceptor：research HE Xin—b01 Yi-cha01’2，XIAO Dianl，QIQian-qianl，2，ZHAOGuo-min91，ZHOU and Medical (1．InstituteofPharmacologyToxicology，AcademyofMilitary Sciences，＆班昭100850，China； 2．SchoolPharmaceutical Pharmaceutical 1 of Engineering，ShenyangUniversity，Shenyang10016，China) of re· [Abstract]Ot-Amino-3-hydroxyl-5-methyl-4-isoxazole—pmpionicacid(AMPA)receptor，asubtypeionotropicglutamate inthe membraneofthecentralnervous mostofthefast neurotransmission． ceptors postsynaptic system(CNS)，mediatesexcitatory CX717 CodexPharmaceuticalsoftheUSA tothebenzamideseriesofAMPA modula- developedby Company belongs receptorpositive tots．ItCanreducethe ofAMPA or inactivation is relat— speed receptor desensitization，therebyenhancingsynapticactivity，andclosely edtothetreatmentofAlzheimer’s andattentiondeficit disease，Parkinson’Sdisease，depression hyperactivity article of its reviewsthelates