《HSPA5基因3’非翻译区多态性与肝细胞癌预后的关系》.pdfVIP

·论著· HSPA5基因3 7非翻译区多态性与肝细胞癌预后的关系 潘东晓， 申鸿卓， 王金龙， 叶伟成， 胡树珍， 祁岩超， 朱萧 (广州医学院附属肿瘤医院肿瘤研究所，广州医学院附属肿瘤医院检验科，广东广州510095) 【摘要】 目的调查70 体型和双体型不影响生存。多重比较结果显示临床特征与病人总的预后无关(P0．05)。结论中国人HSPA5基因3’非 翻译区的变异对HCC的预后没有明显影响。 【关键词】热体蛋白5；肝细胞癌；多态性；预后 Associationbetweenthe inthe3’IYrRofHSPA5and carcinoma PAN Dong- polymorphisms genehelmtocellularprognosis Xiao．CancerInstituteand 茹洳，SHENHong-zhuo，WANGJing-long，YEWei-cheng，HUShu-zhen，QiYan—chao，ZHU Depart- merit Medwd of Medwine，Cancer Unwersi砂，Guanzghou510095，China Laboratory Hospital，Guangzhou To the associationbetweenthe inthe3’untranslated 【Abstract】Objectiveinvestigatedpossible polymorphisms region fromblood of288 Was HSPA5and DNA HCC (UTR)of samples hepatocellularcarcinoma(HCC)prognosis．Methods patients for 140763andm12009 methodand testwereusedtoesti— typedral byTaqManassays．TheKaplan-Meierlog-rank mateoverallsurvival．ResultsThedistributionof wasnotrelatedtotheclinical haplotype analysis thatthe and didnoteffectthesurvival．Noneoftheclinicalfeaturesshowa showed allele，genetype，haplotypediplotype significant overall outcomein Thereisno influenceof3’ association(P0．05)with patient multiplecomparisons．Conclusionnoteworthy HCCin Chinese UTR intheHSPA5on of