《Microwave assisted convenient synthesis of quino[2,3-b][1,5]benzoxazepines》.pdfVIP

下载本文档

6
0
约2.58万字
约 8页
2015-12-09 发布于河南
举报
版权申诉

《Microwave assisted convenient synthesis of quino[2,3-b][1,5]benzoxazepines》.pdf

1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
7、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

《Microwave assisted convenient synthesis of quino[2,3-b][1,5]benzoxazepines》.pdf

Available online at Chinese Chemical Letters 20 (2009) 557–561 /locate/cclet Microwave assisted convenient synthesis of quino[2,3-b][1,5]benzoxazepines Swapnil S. Sonar a, Sandip A. Sadaphal a, Shivaji S. Pawar b, Bapurao B. Shingate c, Murlidhar S. Shingare a,* a Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad 431004, MS, India b Department of Chemistry, Vinayakrao Patil Mahavidyalaya Vaijapur, Aurangabad 423701, MS, India c National Chemical Laboratory, Pune 411008, MS, India Received 23 October 2008 Abstract A convenient synthesis of quino[2,3-b][1,5]benzoxazepines from substituted 2-chloroquinoline-3-carbaldehyde and 2-hydroxy aniline by using stable, non-toxic and inexpensive catalyst 1,8-diazabicyclo-undecan-7-ene (DBU)/silica gel is described. This method affords the quino[2,3-b][1,5]benzoxazepines under the inﬂuence of microwave irradiation (360 W) in solvent-free conditions within short reaction times (2–3 min), giving high yields of products (93–96%). # 2009 Murlidhar S. Shingare. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved. Keywords: Quino[2,3-b][1,5]benzoxazepines; DBU/silica gel; Microwave irradiation; Solvent-free Quinoline ring system represents the major class of heterocycles as they occur in various natural products especially in alkaloids [1]. It possesses diverse biological and physiological activities such as antimalarial [2a], anti- inﬂammatory [2b], antitum