《Preparation of (#177;)-5,6,7-Trioxygenated Dihydrofiavonols and Evaluation of their Superoxide Radical Scavenging Activity》.pdfVIP

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《Preparation of (#177;)-5,6,7-Trioxygenated Dihydrofiavonols and Evaluation of their Superoxide Radical Scavenging Activity》.pdf

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《Preparationof(amp;#177;)-5,6,7-TrioxygenatedDihydrofiavonolsandEvaluationoftheirSuperoxideRadicalScavengingActivity》.pdf

Chinese Chemical Letters Vol. 17, No. 4, pp 449-452, 2006 449 /journal/ccl.html Preparation of (±)-5,6,7-Trioxygenated Dihydroflavonols and Evaluation of their Superoxide Radical Scavenging Activity 1 1 1 1 1 Jing Xu GONG , Yu Bin FENG , Feng WANG , Yan Guang WANG , Hai Bo LI , Yi Hang WU1 2 3 3 , Xiao Jiang HAO , Xiu Mei WU , Hua BAI , Joachim STÖCKIGT1,4 1 , Yu ZHAO ∗ 1Department of Traditional Chinese Medicine and Natural Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310031 2The Key Laboratory of Chemistry of Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550022 3Zhejiang Hisun Naturelite Pharmaceutical RD Co., Ltd., Hangzhou 310007 4 Lehrstuhl für Pharmazeutische Biologie, Institut für Pharmazie, Johannes-Gutenberg Universität Mainz, D-55099 Mainz, Germany Abstract: The synthesis of (±)-5, 6, 7-trioxygenated dihydroflavonols was carried out. All synthetic compounds were passed through superoxide radical scavenging activity in vitro. Compounds 1 e and 1 g exhibited significant bioactivity with the inhibitory rates of 68.1% and 80.9% at 40 µg/mL, respectively. Keywords: Dihydroflavonol, (±)-5,6,7-trioxygenated-dihydroflavonols, total synthesis, antioxidant, superoxide radical scavenging. . Free radicals for example superoxide radicals (O2 –) ma