《Re-expression of RASSF1A by 5-Aza-CdR Induced Demethylation of the Promoter Region in Human Biliary Tract Carcinoma Cells》.pdfVIP

Journalof ofScienceand [Med Huazhong Sci] University Technology 27(3)：281-284，2007 DOI101007／sl1596．007．0316。6 281 Induced ofRASSFlA5-Aza--CdRDeme of Re--expressionby thylation thePromoterinHumanTractCarcinomaCells木 Region Biliary ZUO shi(左石)1一，CHENYongjun(陈勇军)1，xuLining(徐立宁)1，TANGQibin(唐启彬)3 General Medical 。Department University, of Surgery,TongjiHospital,TongjiCollege,HuazhongScience＆Technology Wuhan 430030,China Medical 550004,China 2DepartmentofhepatobiliarySurgery,theaffiliatedhospitalofGuiyangCollege，Guiyang Yat—sen 510120,China 3DepartmentofhepatobiliarySurgery,theSecondAffiliatedHospitalofSun University,Guangzhou ofthe isan meanforthe Summary：Hypermethylationpromoterregion important ofanumberofcancer-associated and／orincreasedof repression genes，andover-expression activity DNA areconsideredtobethemaincauseof order methyltransferase promoterhvpermethylation．In tofurther the mechanismoftumor RASSFlAinactivation． exploreepigenetic suppressorgeRe f5一Aza—CdR)，aDNA usedtotreatthehuman 5一aza一2’一deoxycytidine methyltransf