《Synthesis and Anti-influenza Virus Activity of Ethyl 6-Bromo-5-hydroxyindole-3-carboxylate Derivatives》.pdfVIP

Chinese Chemical Letters Vol. 15, No. 9, pp 1039-1042, 2004 1039 /journal/ccl.html Synthesis and Anti-influenza Virus Activity of Ethyl 6-Bromo-5-hydroxyindole-3-carboxylate Derivatives Yan Fang ZHAO, Jin Hua DONG, Ping GONG* Shenyang Pharmaceutical University, Shenyang 110016 Abstract: A series of ethyl 6-bromo -5-hydroxyindole-3-carboxylate derivatives were synthesized and their in vitro anti-influenza virus activity was evaluated. All the compounds were characterized 1 by H NMR and MS . Keywords: Ethyl 6-bromo -5-hydroxyindole-3-carboxylate derivatives , synthesis, anti-influenza virus activity. Worldwide influenza pandemics have occurred at irregular and unpredictable intervals throughout history. The impact of pandemic influenza is substantial in terms of morbidity, mortality and economic cost. The chemotherapy options were limited to admantidine or rimantidine, which are only effective against influenza A and often cause side-effects and rapid viral resistance. Recently the launch of the neuraminidase inhibitors zanamivir and oseltamivir give a new option. Nevertheless, the improvement 1 of these options still remains need .. CH N(CH )