《Synthesis of 5,10,15,20-Tetra(N-methyl-6-quinolyl)-21,23-dithiaporphyrin Chloride as Cationic Core-modified Porphyrin》.pdfVIP

Chinese Chemical Letters Vol. 15, No. 11, pp 1261-1264, 2004 1261 /journal/ccl.html Synthesis of 5,10,15,20-Tetra(N-methyl-6-quinolyl)-21,23-dithia- porphyrin Chloride as Cationic Core-modified Porphyrin 1 2 Tao LU *, Laurence H. HURLEY 1Department of Organic Chemistry, China Pharmaceutical University, Nanjing 210009 2College of Pharmacy and Arizona Cancer Center, University of Arizona, Tucson AZ85742, USA Abstract: First cationic 6-quinolyl substituted dithiaporphyrin was synthesized using Skraup quinoline methodology from thiaporphyrin bearing 4-acetamidophenyl prepared by condensation reaction of aromatic aldehyde with pyrrole. Keywords: Porphyrin, thiaporphyrin, telomerase inhibitor, dilithiophen. Telomeres are specialized DNA-protein complexes at ends of chromosomes, which 1 represent a potential target for novel anti -cancer agents . Since Zahler and co-workers + demonstrated in 1991 that K -stabilized G-quadruplex structures were able to inhibit telomerase, G-quadruplex DNA has emerged as an attractive target for telomerase