中国医科大学病理学英文课件2.ppt

(2) Fatty change of myocardium ① Local type The common site Subendocardium papilary muscle Gross: Tigered effect apparent bands of yellowed myocardium alterating with bands of darker, red- brown(uninvolved) myocardium LM: string of bead-like small droplets near the nucleus ② Diffuse type: Cause: severe hypoxia or poisoning Lesion: diffuse light yellow Fatty change of myocardium Myocardial fatty infiltration: Different from myo-fatty change: In subpericardial, excessive fat accumulating and inserting among myocardial bandles. Causes: obvious obesity, alcohol abuse Sudden death Myocardial fatty infiltration (3) Fatty change of renal  tubule epithelium Causes lipoprotein↑ reabsorption of lipoprotein↑ LM: droplets within proximal tubule epithelium (4) Cholesterol or cholesterol ester ① Atherosclerosis: cholesterol crystal ② Xanthoma: Macrophage phagocyte cholesterol foam-like ③ Inflammation and necrosis:foam cell ④cholesterolosis of gallbladder: Deposition of cholesterol 3.Hyaline change(degeneration) Definition: an alteration within cells, in the extracellular space and walls of arterioles which gives a homogeneous glassy, pink appearance Accumulations of Protein within the cell extracellular space (1) Walls of arterioles: ① Hypertension: walls of arterioles, in the kidney, brain, spleen, retina ② Arteriolosclerosis Hyaline change of central artery Sclerossis of renal afferent artery (2) Connective tissue: ① Site: old scars, fibrous plaque (AS) ② Gross: gray, glassy appearance ③ LM: homogeneous ,pink ,beam-like substance Hyaline change of pleura (3) Within cells: ① Reabsorbed droplets: varies in size