肺功能不全 - 中山大学精品课程.pptVIP

Respiratory Failure Functional shunt and  Anatomic shunt Anatomic shunt No blood –gas exchange Applying O2 can’t increase PaO2 Functional shunt blood –gas exchange decrease Applying O2 can increase PaO2 Pathogenesis of ARDS Stimulus Complement activation Pulmonary edema Lysosomal proteinase Active oxygen Pulmonary vasoconstiction Arachidonic acid metabolites Epithelial and endothelial Cell damage C5a Sequestration of neutrophils in lungs Increased pulmonary permeability Pulmonary hypertension Pathophysiology of ARDS causative factor alveolar-ca