EPO对宫内感染脑白质损伤早产大鼠脑组织CD68、GFAP水平和神经行为学的影响.pdf

治疗作用。 3．早期应用rhEPO可以改善宫内感染脑白质损伤的早产大鼠神经系统发育及认 知功能。 硕士研究生杨琳 (儿科学专业) 指导教师 姜红 教授 关键词：宫内感染；早产；大鼠；脑白质损伤；促红细胞生成素；CD68； 胶质纤维酸性蛋白；神经行为学 InfluencesofEPOonBrainTissuesof PrematureRatswith InfectionWMD Leveland includingCD68，GFAPNeuroethology Abstract the effectofrhEPOon ratswith objective：ToStudyneuroprotective premature intrauterineinfectionWMD detectionofthe inCD68and in through changes GFAPbrain tissueandassessmentof neuroethology． Method：Selected20wistarratsthathadbeen for15danddividedtheminto pregnant infection control ratio3：1 at group(n=15)and group(n=5)by of saline intraperitonealinjection LPS(0．3mg／Kg)andequivalentstroke-physiological solutionon15th ofWistarratsin day’Spregnancy both andconducted groupsrespectively cesarean sectiontotakeoutfetalratson21thday’Spregnancy；observed pathological outfetal newratbrain changesbytaking rats(n=10)and tissue(n=1 eosin 0)hematoxylin intwo selected40newbornratsinthe (HE)staininggroupsrespectively；randomly control asthe birthcontrol group 80newbomratsinthe premature group；selected infectionand into dividedEPOtr