1DecouplingtheRoleofUbiquitinationfortheDislocation.PDFVIP

JBC Papers in Press. Published on June 25, 2013 as Manuscript M113.482018 The latest version is at /cgi/doi/10.1074/jbc.M113.482018 Decoupling the Role of Ubiquitination for the Dislocation vs. Degradation of Major Histocompatibility Complex (MHC) Class I Proteins during Endoplasmic Reticulum-associated Degradation (ERAD)* Xiaoli Wang, Y.Y. Lawrence Yu, Nancy Myers, and Ted H. Hansen From the Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110 *Running title: Non-substrate deubiquitination required for ERAD dislocation To whom correspondence should be addressed: Xiaoli Wang, Department of Pathology and Immunology, Washington University School of Medicine, 660 S. Euclid Ave., St. Louis, MO 63110, USA, Tel.: (314)- 362-3972; Fax: (314)-362-4137; E-mail: xiwang@; and Ted H. Hansen, Department of Pathology and Immunology, Washington University School of Medicine, 660 S. Euclid Ave., St. Louis, MO 63110, USA, Tel.: (314)-362-2716; Fax: (314)-362-4137; E-mail: hansen@ Keywords: ER-associated degradation; dislocation; ubiquitination; MHCI quality control D o w n Background: Whether ubiquitination of ERAD heavy chains was found not to require potential l