Comparativestudyofchemicalsynthesisofpyrimidine.PDFVIP

Available online at www.ilcpa.pl International Letters of Chemistry, Physics and Astronomy 14(1) (2014) 22-27 ISSN 2299-3843 Comparative study of chemical synthesis of pyrimidine derivatives by using Grindstone chemistry Technique and Conventional method Ratnamala P. Sonawane The Institute of Science, Mumbai 400032, India E-mail address: ratnasonawane@yahoo.in ABSTRACT The majority of the drugs on the market today are entirely chemically synthesized in the laboratory. Several scientists had synthesized dihydropyrimidine (DHPMs) derivatives showing a wide spectrum of biological actions as antibacterials, antivirals as well as antitumor agents. This activity is principally due to presence of steriogenic carbon C4 in their structure. The current investigation is comparative study of chemically synthesis of two DHPMs derivatives by Biginelli Reaction using conventional method and grindstone chemistry technique. The synthesis of DHPMs derivative involves a multicomponent reaction (aldehyde derivative, urea /thiourea and 1,3- dicarbonyl compounds) in presence of HCl / NH Cl as a catalyst. Two derivative viz. 3,4- 4 dihydropyrimidin-2-(1H)-ones and 3,4-dihydropyrimidin-2-(1H)-thiones were synthesized and characterized using IR. The melting points were obtained are 208 °C and 210 °C respectively. “Grindstone Chemistry Technique” catalyzed by CuCl ·2H O and Conc. HCl. gave more