ContributionofShapeandGradientRefractiveIndextothe.PDFVIP

Lens Contribution of Shape and Gradient Refractive Index to the Spherical Aberration of Isolated Human Lenses Judith Birkenfeld, Alberto de Castro, and Susana Marcos ´ ´ Instituto de Optica ‘‘Daza de Valdes,’’ Consejo Superior de Investigaciones Cientıficas (CSIC), Madrid, Spain Correspondence: Judith Birkenfeld, PURPOSE. To estimate the contribution of 3-dimensional (3D) lens geometry and gradient Serrano, 121, 28006, Madrid, Spain; refractive index (GRIN) to the lens spherical aberration (SA) with age. j.birkenfeld@io.cfmac.csic.es. METHODS. A total of 35 donor human lenses (19–71 years) were imaged with 3D-spectral Submitted: February 19, 2014 optical coherence tomography (sOCT). Paraxial and nonparaxial back focal length were Accepted: March 20, 2014 measured with laser ray tracing (LRT). The parameters of a 4-variable 3D GRIN model were Citation: Birkenfeld J, de Castro A, reconstructed from the data using a global search algorithm. Spherical aberration was Marcos S. Contribution of shape and calculated for GRIN lenses and their corresponding homogeneous lenses. gradient refractive index to the spherical aberration of isolated human RESULTS. Lens thickness and radii of curvature increased significantly with age. Negative lenses. Invest Ophthalmol Vis Sci . anterior conic constant shifted toward more-positive values (slope: 0.228, P 0.001), 2014;55:2599–2607. DOI:10.1167/ whereas posterior values remained almost constant (slope: 0.0275, P ¼ 0.002). We found a iovs.14-14201 minor decrease and a small significant increase of nucleus and surface refractive index,