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中国医学影像技术 2012年第 28卷第 7期 ChinJMedImagingTechnol,2012,Vol28,N
·◆.中枢神经影像学
W orkingmemorydeclineand graymatteratrophyin healthy
agedpeople:A voxel—basedmorphometrystudy
ZHENG Dong—ming ,SUN Hong—z& 。。DONGXiao—yu ,CHEN Si—pan ,
XU Yong—chua;rl ,MA Ying ,WANG Xiao—uring
(1.DepartmentofNeurology,2.DepartmentofRadiology,ShengJingHospitalof
ChinaM edicalUniversity,Shenyang 110004,China)
[Abstract] Objective Toexploretherelationshipbetweenthedeclineofworkingmemoryandgraymatteratrophyinnor—
realagingwithvoxel-basedmorphometry(VBM)method.Methods Keep-tracktaskand2-hacktaskwereusedtoobserve
workingmemoryin30oldpeople(agedgroup)and38youngpeople (controlgroup).HighresolutionMR scanwasper—
formedinallparticipants,andMRIdatawereanalyzedusingVBM with statisticalparametricmapping (SPM)8.Gray
mattervolumeofthetwogroupswerecompared,whileintheagedgroupmultipleregressionwasdonebetweengraymatter
volumeandthebehavioralscoresofthetwoworkingmemorytaskstofindatrophicbrainareasresponsibleforthedeclineof
workingmemory.Results Comparedwithcontrolgroup,theagedgroupshowed significantdeclineofworkingmemory
andwidegraymatteratrophy.Intheagedgroup,atrophyofgraymatterassociatedwith low scoreinkeep—tracktaskwas
foundinbilateralmiddleandinferiorprefrontalcortex,premotorcortex,posteriorparietallobesandcerebellum.Atrophy
ofgraymatterassociatedwithhigherrorratein2-backtaskwasfoundin leftinferiorprefrontalcortex,premotorcortex
andtemporallobe.Thevolumeofgraymatterofleftventralpremotorcortex (BA6)wasrelatedtobothbehavioralscores
inthetwoworkingmemorytasks.Conclusion Thedeclineofworkingmemory inhealthyagingisrelatedtograymatter
atrophyoftheworkingmemoryneuralnetwork.
[Keywords] Workingmemory;Magneticresonanceimaging;Brain
应
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