生物学 英文ppt.pptVIP

Prion related disease caused by an Infectious Protein Infectious Disease Infectious disease is caused by the TRANSMISSION of an AGENT to a HOST The MULTIPLICATION of the AGENT within the HOST The agents of infectious disease have been studied widely and are generally either Bacteria Viruses Protozoa Fungi Infectious Protein In the past thirty years there has been increasing evidence that some molecules may be infectious In particular a protein molecule called a PRION Prion Diseases Diseases of animals and man The disease affects the brain and spinal cord The disease can be passed on by ingestion of prions in food Injection of prion contaminated material and by tissue transplant CJD First recognised in South Africa A brain disease affecting people who had received injections of human growth hormone The growth hormone had been taken from the pituitary gland in the brain of dead people Kuru In the 1950’s a disease of tribes people in the Kuru mountain region of New Guinea Disease only seen in females and children not adult males Associated with ritual canabalism Brain tissue consumed as a mark of respect for the dead by females Symptoms of KURU Senile dementia, loss of motor function, loss of sensory function, total collapse of nerve function Patients died within two years of onset of symptoms KURU and CJD The brains of individuals that had died from KURU were examined They were found to resemble those of individuals that had died from CJD Kuru No longer affects the peoples of New Guinea Tribes have been educated about the risks and no longer practice ritual canablism Scrapie In 1973 A disease of sheep was discovered with symptoms similar to CJD and KURU UK had greatest number of scrapie infected sheep in the entire world BSE Mid 1980 First cases of a progressive neurological disease in cattle seen BSE and nvCJD Greatest number of BSE cases in the UK The disease appears to have spread to man A new form of CJD has emerged in people in the