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Biomarkers for enhancing the radiosensitivity of nasopharyngeal carcinoma.pdf
CancerBiolMed2015;12:23—32.doi:10.7497/j.issn.2095—3941.2014.0015
REVIEW
BiomarkersforenhancingtheradiosensⅢVityof
nasopharyngeaIcarcinoma
WeiChen,Guo—HuaHu
DepartmentofOtorhin。laryngoIog theFirstAffiliatedHospitalofChongqingMedicalUniversity,Chongqing400016,China
Nasopharyngealcarcinoma(NPC)isacommonheadandneckmalignancy.TheincidenceofNPCishigherinSouthern
ChinaandSoutheastAsiacomparedwithW esterncountries.Givenitshighradiosensitivity,thestandardtreatmentfor
NPC isradiotherapyHowever,radioresistanceremainsaseriousobstacletosuccessfu1treatment.Radioresistancecancause
localrecurrenceanddistantmetastasesinsomepatientsaftertreatmentbyradiation.ThusJspecialemphasishasbeengiven
tothediscoveryofeffectiveradiosensitizers.Th isreview aimstodiscussthebiomarkersJclassifiedaccordingtothemain
mechanismsofradiosensitization,whichcanenhancethesensitivityofNPCcellstoionizingradiation.
Nasopharyngealcarcinoma(NPC);radiotherapy;radiosensitization;biomarkers
incidenceinSOUthernpartsofChinaandSoutheastAsia,usually
Introduction
belongingtotypesIIandIll,ishigherthanthatinW estern
Nasopharyngea1carcinoma(NPC)isahighlymetastatic countries.IntheWestINPC occurssporadicallyandusually
cancerthatoriginatesfrom theepithelialliningofthe belongstotypeI.
nasopharynx.NPCoccursmostlyinthepharyngealrecess Distinguishedby itsuniqueclinicalandpathologic
(fossaofRosenmfiller)andtheeustachiantubeopening characteristicsJNPC ishighlyradiosensitive.Comparedwith
inthenasopharynx.Comparedwith otherheadandneck typeI,typesIIandIIIhaveahigherresponseratetoionizing
malignancies,NPC isuniqueintheaspectsofepidemiology, radi
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