A novel protein-repellent dental composite containing 2-methacryloyloxyethyl phosphorylcholine.pdfVIP
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A novel protein-repellent dental composite containing 2-methacryloyloxyethyl phosphorylcholine.pdf
InternationalJournalofOralScience(2015)7.103-109
@ 2015WCSS.Allrightsreserved1674-2818/15
www.nature.com/ijos
ORIGINALARTICLE
Anovelprotein--repellentdentalcompositecontaining
2一methaCry10y10XyethyIph0Sph0ryICh0Iine
NingZhang ,ChenChen ,MaryASMelo,Yu—XingBai2,LeiCheng。andHockinHKXu ,4,’
SecondarycariesduetobiofJimacidsisaprimarycauseofdentaIcompositerestorationfailure.Todate.therehavebeennoreports
ofdentaIcompositesthatcanrepeIproteinadsorptionandinhibitbacteriaattachment.Theobjectivesofthisstudyweretodevelopa
protein-repellentdentaIcompositebyincorporating2-methacryloyloxyethylphosphorylcholineM【PC)andtoinvestigateforthefirst
timetheeffectsofMPCmassfractiononproteinadsorption,bacteriaattachment,biofJim growth,andmechanicaIproperties.
Compositesweresynthesizedwith0(contro1),0.75%,1_5%。2.25%,3%,4.5%and6%ofMPCbymass.AcommerciaIcomposite
wasalsotestedasacontroI.MechanicaIpropertiesweremeasuredinthree-pointflexure.Proteinadsorptionontothecompositewas
determinedbythemicrObicinchOninicacidmethod.Ahumansalivamicrocosm biofilm mode1wasused.Earlyattachmentat4h.
biofilm at2days.Iive/deadstainingandcolony·formingunits(CFUs)ofbiofilmsgrownonthecompositeswereinvestigated.
CompositeswithMPCofupto3% hadmechanicalpropertiessim_lartothosewithoutMPCandthoseofthecommerciaIcontro1.
whereas4.5% and6% MPCdecreasedthemechanicaIproperties(P0.05).IncreasingMPCfrOm 0tO3% reducedtheprotein
adsorptiononcomposites【P0.05).Thecompositewith3%MPChadproteinadsorptionthatwas1/12thatofthecontroI
(P0.05).0raIbacteriaearlyattachmentandbiofilmgrowthwerealsogreatlyreducedonthecompositewith3%MPC,comparedto
thecontroI(P0.05).1nconclusion。incorporationofMPCintocompositesat3%greatlyreducedproteinadsorption,bacteria
attachmentandbiofilm CFUs.withoutcompromisingmechanica
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