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Cell Surface Transmembrane Protein Database for Detecting Potential Targets of Antibody Drug in Application of Cancer Therapies.pdf

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Cell Surface Transmembrane Protein Database for Detecting Potential Targets of Antibody Drug in Application of Cancer Therapies.pdf

Dec．2010，Volume4，No．7(SerialNo．32) JournalofLifeSciences，ISSN 1934-7391，USA CellSurfaceTransmembraneProteinDatabasefor DetectingPotentialTargetsofAntibodyDrugin ApplicationofCancerTherapies Po．Yuan Chen ，Cheng．Shang Kao，M ien．De Jhuo，Tzu．Hurng Cheng，Wei．Tse Hsu Che．Yen Ou。，， Tzu—ChingShih andChieh—HsiW u 』．DepartmentofBiologicalScienceandTechnology，ChinaMedicalUniversity，Taichung404，Taiwan 2．Parexel-ApexInternational，Taipei，Taiwan 3．DepartmentofMedicalRadioloyg Technoloyg,ChinaMedicalUniversityandDepartmentofRadioloyg,ChinaMedicalUniversiyt Hospital,Taichung404，Taiwan 4DepartmentofPharmacy,ChinaMedicalUniversiyt,Taichung404，Taiwan Received：M ay20，2010／Accepted：August07，2010 ／Published：December30，2010 Abstract：Background：Antibodydrugco~ugated(ADC)isonekindofveryimportantmethodoftherapytocnacerdiseases．Inthis research，theauthorsintroduceBLAST andsomeotherimportantalgorithmstoereatetransmembraneprotein databases．These databasesareacquired from well-known databases such asNCBIorSwiss．Protastemplate．and then collectallpossible transmembraneproteinbyusingBLASTorphysicalchraacter．Atiercollectthees databases．theauthorswillaim ateachnucleotide sequencesto designtheprobesofoligonucleotidemicroarray，which candetectthehighexpresstransmembraneproteinsvery em ciently．Finally．theauthorscanacceleratethenati．cancerdrugdiscovery byusingthesedatabases．Result：Thisstudyconstructeda webservice，theTransmembrna eProteinDatabase，toreserachersthatraeinterestedinorneedtooligonucleotidemicroarrayprobe designfordetectingpotentialtargetsofantibodydrug．Withuserfriendlywebbasedwindowscontainingeachnecessaryselections， userscaneasilychoosetheparametersandgetthesuitableprobedesignsuggestions．Conclusion：Transmembrnaeproteindatabaseis very importantna dpowerfulindetectingcancersorotherhumna disease．Byusingthisdatabase，theauthorsofferagoodstrategyin transmemb