Analgesis and Wound Healing Effect of Chitosan and Carboxymethyl Chitosan on Scalded Rats.pdfVIP

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Analgesis and Wound Healing Effect of Chitosan and Carboxymethyl Chitosan on Scalded Rats.pdf

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Analgesis and Wound Healing Effect of Chitosan and Carboxymethyl Chitosan on Scalded Rats.pdf

J．OceanUniv．China (OceanicandCoastalSeaResearch1 D0I10．1007／sl1802—014．2285．2 ISSN1672—5182，201413(5)：837—841 ftp：／／www．ouc．edu．cn／xbywb／ E-mail：xbywb@OUC．edu．cn AnalgesisandW oundHealingEffectofChitosanand CarboxymethylChitosanonScaldedRats HUANG Shuya，HAN Baoqin，SHAO Kai，YU M iao，andLIU Wanshun CollegeofMarineLifeSciences，OceanUniversityofChina，Qingdao266003，P．R．China (ReceivedJanuary23，2013：revisedApril15，2013；acceptedApril25，2014) @ OceanUniversityofChina．SciencePressandSpring-VerlagBerlinHeidelberg2014 Abstract Analgesisandwoundhealingeffectofchitosanandcarboxymethylchitosanonscaldedratswereinvestigated．A IIde— greescaldmodelwasestablishedinrats．whichwassubsequentlytreatedwithchitosanandcarboxymethy1chitosansolution．respec— tively．Theconcentrationofbradykininand5-hydroxytryptophanwasdetectedbyassayingenzyme—linkedimmunosorbent．Healing conditionwasobservedandpathologicalsectionsweremadetodeterminethehealingeffectofchitosna andcarboxymethylchitosan． Resultsshowedthattheconcentrationofbradykininna d5-hydroxytryptophanpeakedatthethirdhourpost．woundinallgroups， whiletheconcentrationofhydroxyprolinepeakedattheseventhdaypost．woundinbothchitosanandca~oxymehtylchitosangroup． Theconcentrationofbradykininand5-hydroxytryptophanofcarboxymethy1chitosangroupwassignificantlylowerthanthatofcon一仃ol 0．05)，whilethatofchitosangroupwassimilartothatofcontrol 0．05)．Thesefindingsindicatedthatcarboxymethyl chitosan reduced theconcenrtation ofalgogenicsubstances，resultingi11analgesia．During thewholerecovery process，thehy— droxyprolineconcenrtationinchitosanandcarboxymethylchitosangrouponday3na d7wassignificantlyhigherthanmatOfcontro1 0．011：howeverthesignificnaceofsuchahighnessdecreasedonday14(尸0．05)．Thesefindingsindicatedthatchitosanand carboxymehtylchitosna acceleratedtissuerepair．Meanwhile．chitosanperformedbetterinhealingthancarboxymethylchitosanin bothdecmsattionandhealingtime．Inconclusion．carboxymethY1chitosanshowedsignificantanalgesisandwound．healingpro